Bubble charts encode data in the area of circles. Although less perceptually-accurate than bar charts, they can pack hundreds of values into a small space. Implementation based on work by Jeff Heer. Data shows the Flare class hierarchy, also courtesy Jeff Heer.
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Bubble Chart
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| license: gpl-3.0 | |
| height: 960 | |
| border: no |
We can make this file beautiful and searchable if this error is corrected: It looks like row 22 should actually have 11 columns, instead of 4. in line 21.
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| fullName shortName oneLetterCode sideChainClass sideChainPolarity sideChainCharge Hidropathy Absornace at MW Occurence | |
| Alanine Ala A aliphatic nonpolar neutral 1.8 89.094 8.76 | |
| Arginine Arg R basic basic polar positive −4.5 174.203 5.78 | |
| Asparagine Asn N amide polar neutral −3.5 132.119 3.93 | |
| Aspartic acid Asp D acid acidic polar negative −3.5 133.104 5.49 | |
| Cysteine Cys C sulfur-containing nonpolar neutral 2.5 250 0.3 121.154 1.38 | |
| Glutamic acid Glu E acid acidic polar negative −3.5 147.131 6.32 | |
| Glutamine Gln Q amide polar neutral −3.5 146.146 3.9 | |
| Glycine Gly G aliphatic nonpolar neutral −0.4 75.067 7.03 | |
| Histidine His H basic aromatic basic polar neutral −3.2 211 5.9 155.156 2.26 | |
| Isoleucine Ile I aliphatic nonpolar neutral 4.5 131.175 5.49 | |
| Leucine Leu L aliphatic nonpolar neutral 3.8 131.175 9.68 | |
| Lysine Lys K basic basic polar positive −3.9 146.189 5.19 | |
| Methionine Met M sulfur-containing nonpolar neutral 1.9 149.208 2.32 | |
| Phenylalanine Phe F aromatic nonpolar neutral 2.8 257, 206, 188 0.2, 9.3, 60.0 165.192 3.87 | |
| Proline Pro P cyclic nonpolar neutral −1.6 115.132 5.02 | |
| Serine Ser S hydroxyl-containing polar neutral −0.8 105.093 7.14 | |
| Threonine Thr T hydroxyl-containing polar neutral −0.7 119.119 5.53 | |
| Tryptophan Trp W aromatic nonpolar neutral −0.9 280, 219 5.6, 47.0 204.228 1.25 | |
| Tyrosine Tyr Y aromatic polar neutral −1.3 274, 222, 193 1.4, 8.0, 48.0 181.191 2.91 | |
| Valine Val V aliphatic nonpolar neutral 4.2 117.148 6.73 | |
| Selenocysteine Sec U 168.064 | |
| Pyrrolysine Pyl O 255.313 |
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| // https://d3js.org Version 4.10.2. Copyright 2017 Mike Bostock. | |
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3:this.point(this._x2,this._y2),this.point(this._x3,this._y3),this.point(this._x4,this._y4)}},point:function(t,n){switch(t=+t,n=+n,this._point){case 0:this._point=1,this._x2=t,this._y2=n;break;case 1:this._point=2,this._x3=t,this._y3=n;break;case 2:this._point=3,this._x4=t,this._y4=n,this._context.moveTo((this._x0+4*this._x1+t)/6,(this._y0+4*this._y1+n)/6);break;default:Ga(this,t,n)}this._x0=this._x1,this._x1=t,this._y0=this._y1,this._y1=n}};Ka.prototype={areaStart:function(){this._line=0},areaEnd:function(){this._line=NaN},lineStart:function(){this._x0=this._x1=this._y0=this._y1=NaN,this._point=0},lineEnd:function(){(this._line||0!==this._line&&3===this._point)&&this._context.closePath(),this._line=1-this._line},point:function(t,n){switch(t=+t,n=+n,this._point){case 0:this._point=1;break;case 1:this._point=2;break;case 2:this._point=3;var e=(this._x0+4*this._x1+t)/6,r=(this._y0+4*this._y1+n)/6;this._line?this._context.lineTo(e,r):this._context.moveTo(e,r);break;case 3:this._point=4;default:Ga(this,t,n)}this._x0=this._x1,this._x1=t,this._y0=this._y1,this._y1=n}};tc.prototype={lineStart:function(){this._x=[],this._y=[],this._basis.lineStart()},lineEnd:function(){var t=this._x,n=this._y,e=t.length-1;if(e>0)for(var r,i=t[0],o=n[0],u=t[e]-i,a=n[e]-o,c=-1;++c<=e;)r=c/e,this._basis.point(this._beta*t[c]+(1-this._beta)*(i+r*u),this._beta*n[c]+(1-this._beta)*(o+r*a));this._x=this._y=null,this._basis.lineEnd()},point:function(t,n){this._x.push(+t),this._y.push(+n)}};var Gg=function t(n){function e(t){return 1===n?new Ja(t):new tc(t,n)}return e.beta=function(n){return t(+n)},e}(.85);ec.prototype={areaStart:function(){this._line=0},areaEnd:function(){this._line=NaN},lineStart:function(){this._x0=this._x1=this._x2=this._y0=this._y1=this._y2=NaN,this._point=0},lineEnd:function(){switch(this._point){case 2:this._context.lineTo(this._x2,this._y2);break;case 3:nc(this,this._x1,this._y1)}(this._line||0!==this._line&&1===this._point)&&this._context.closePath(),this._line=1-this._line},point:function(t,n){switch(t=+t,n=+n,this._point){case 0:this._point=1,this._line?this._context.lineTo(t,n):this._context.moveTo(t,n);break;case 1:this._point=2,this._x1=t,this._y1=n;break;case 2:this._point=3;default:nc(this,t,n)}this._x0=this._x1,this._x1=this._x2,this._x2=t,this._y0=this._y1,this._y1=this._y2,this._y2=n}};var Jg=function t(n){function e(t){return new ec(t,n)}return e.tension=function(n){return t(+n)},e}(0);rc.prototype={areaStart:Zg,areaEnd:Zg,lineStart:function(){this._x0=this._x1=this._x2=this._x3=this._x4=this._x5=this._y0=this._y1=this._y2=this._y3=this._y4=this._y5=NaN,this._point=0},lineEnd:function(){switch(this._point){case 1:this._context.moveTo(this._x3,this._y3),this._context.closePath();break;case 2:this._context.lineTo(this._x3,this._y3),this._context.closePath();break;case 3:this.point(this._x3,this._y3),this.point(this._x4,this._y4),this.point(this._x5,this._y5)}},point:function(t,n){switch(t=+t,n=+n,this._point){case 0:this._point=1,this._x3=t,this._y3=n;break;case 1:this._point=2,this._context.moveTo(this._x4=t,this._y4=n);break;case 2:this._point=3,this._x5=t,this._y5=n;break;default:nc(this,t,n)}this._x0=this._x1,this._x1=this._x2,this._x2=t,this._y0=this._y1,this._y1=this._y2,this._y2=n}};var Qg=function t(n){function e(t){return new rc(t,n)}return e.tension=function(n){return t(+n)},e}(0);ic.prototype={areaStart:function(){this._line=0},areaEnd:function(){this._line=NaN},lineStart:function(){this._x0=this._x1=this._x2=this._y0=this._y1=this._y2=NaN,this._point=0},lineEnd:function(){(this._line||0!==this._line&&3===this._point)&&this._context.closePath(),this._line=1-this._line},point:function(t,n){switch(t=+t,n=+n,this._point){case 0:this._point=1;break;case 1:this._point=2;break;case 2:this._point=3,this._line?this._context.lineTo(this._x2,this._y2):this._context.moveTo(this._x2,this._y2);break;case 3:this._point=4;default:nc(this,t,n)}this._x0=this._x1,this._x1=this._x2,this._x2=t,this._y0=this._y1,this._y1=this._y2,this._y2=n}};var Kg=function t(n){function e(t){return new ic(t,n)}return e.tension=function(n){return t(+n)},e}(0);uc.prototype={areaStart:function(){this._line=0},areaEnd:function(){this._line=NaN},lineStart:function(){this._x0=this._x1=this._x2=this._y0=this._y1=this._y2=NaN,this._l01_a=this._l12_a=this._l23_a=this._l01_2a=this._l12_2a=this._l23_2a=this._point=0},lineEnd:function(){switch(this._point){case 2:this._context.lineTo(this._x2,this._y2);break;case 3:this.point(this._x2,this._y2)}(this._line||0!==this._line&&1===this._point)&&this._context.closePath(),this._line=1-this._line},point:function(t,n){if(t=+t,n=+n,this._point){var e=this._x2-t,r=this._y2-n;this._l23_a=Math.sqrt(this._l23_2a=Math.pow(e*e+r*r,this._alpha))}switch(this._point){case 0:this._point=1,this._line?this._context.lineTo(t,n):this._context.moveTo(t,n);break;case 1:this._point=2;break;case 2:this._point=3;default:oc(this,t,n)}this._l01_a=this._l12_a,this._l12_a=this._l23_a,this._l01_2a=this._l12_2a,this._l12_2a=this._l23_2a,this._x0=this._x1,this._x1=this._x2,this._x2=t,this._y0=this._y1,this._y1=this._y2,this._y2=n}};var tm=function t(n){function e(t){return n?new uc(t,n):new ec(t,0)}return e.alpha=function(n){return t(+n)},e}(.5);ac.prototype={areaStart:Zg,areaEnd:Zg,lineStart:function(){this._x0=this._x1=this._x2=this._x3=this._x4=this._x5=this._y0=this._y1=this._y2=this._y3=this._y4=this._y5=NaN,this._l01_a=this._l12_a=this._l23_a=this._l01_2a=this._l12_2a=this._l23_2a=this._point=0},lineEnd:function(){switch(this._point){case 1:this._context.moveTo(this._x3,this._y3),this._context.closePath();break;case 2:this._context.lineTo(this._x3,this._y3),this._context.closePath();break;case 3:this.point(this._x3,this._y3),this.point(this._x4,this._y4),this.point(this._x5,this._y5)}},point:function(t,n){if(t=+t,n=+n,this._point){var e=this._x2-t,r=this._y2-n;this._l23_a=Math.sqrt(this._l23_2a=Math.pow(e*e+r*r,this._alpha))}switch(this._point){case 0:this._point=1,this._x3=t,this._y3=n;break;case 1:this._point=2,this._context.moveTo(this._x4=t,this._y4=n);break;case 2:this._point=3,this._x5=t,this._y5=n;break;default:oc(this,t,n)}this._l01_a=this._l12_a,this._l12_a=this._l23_a,this._l01_2a=this._l12_2a,this._l12_2a=this._l23_2a,this._x0=this._x1,this._x1=this._x2,this._x2=t,this._y0=this._y1,this._y1=this._y2,this._y2=n}};var nm=function t(n){function e(t){return n?new ac(t,n):new rc(t,0)}return e.alpha=function(n){return t(+n)},e}(.5);cc.prototype={areaStart:function(){this._line=0},areaEnd:function(){this._line=NaN},lineStart:function(){this._x0=this._x1=this._x2=this._y0=this._y1=this._y2=NaN,this._l01_a=this._l12_a=this._l23_a=this._l01_2a=this._l12_2a=this._l23_2a=this._point=0},lineEnd:function(){(this._line||0!==this._line&&3===this._point)&&this._context.closePath(),this._line=1-this._line},point:function(t,n){if(t=+t,n=+n,this._point){var e=this._x2-t,r=this._y2-n;this._l23_a=Math.sqrt(this._l23_2a=Math.pow(e*e+r*r,this._alpha))}switch(this._point){case 0:this._point=1;break;case 1:this._point=2;break;case 2:this._point=3,this._line?this._context.lineTo(this._x2,this._y2):this._context.moveTo(this._x2,this._y2);break;case 3:this._point=4;default:oc(this,t,n)}this._l01_a=this._l12_a,this._l12_a=this._l23_a,this._l01_2a=this._l12_2a,this._l12_2a=this._l23_2a,this._x0=this._x1,this._x1=this._x2,this._x2=t,this._y0=this._y1,this._y1=this._y2,this._y2=n}};var em=function t(n){function e(t){return n?new cc(t,n):new ic(t,0)}return e.alpha=function(n){return t(+n)},e}(.5);sc.prototype={areaStart:Zg,areaEnd:Zg,lineStart:function(){this._point=0},lineEnd:function(){this._point&&this._context.closePath()},point:function(t,n){t=+t,n=+n,this._point?this._context.lineTo(t,n):(this._point=1,this._context.moveTo(t,n))}};dc.prototype={areaStart:function(){this._line=0},areaEnd:function(){this._line=NaN},lineStart:function(){this._x0=this._x1=this._y0=this._y1=this._t0=NaN,this._point=0},lineEnd:function(){switch(this._point){case 2:this._context.lineTo(this._x1,this._y1);break;case 3:pc(this,this._t0,hc(this,this._t0))}(this._line||0!==this._line&&1===this._point)&&this._context.closePath(),this._line=1-this._line},point:function(t,n){var e=NaN;if(t=+t,n=+n,t!==this._x1||n!==this._y1){switch(this._point){case 0:this._point=1,this._line?this._context.lineTo(t,n):this._context.moveTo(t,n);break;case 1:this._point=2;break;case 2:this._point=3,pc(this,hc(this,e=lc(this,t,n)),e);break;default:pc(this,this._t0,e=lc(this,t,n))}this._x0=this._x1,this._x1=t,this._y0=this._y1,this._y1=n,this._t0=e}}},(vc.prototype=Object.create(dc.prototype)).point=function(t,n){dc.prototype.point.call(this,n,t)},_c.prototype={moveTo:function(t,n){this._context.moveTo(n,t)},closePath:function(){this._context.closePath()},lineTo:function(t,n){this._context.lineTo(n,t)},bezierCurveTo:function(t,n,e,r,i,o){this._context.bezierCurveTo(n,t,r,e,o,i)}},yc.prototype={areaStart:function(){this._line=0},areaEnd:function(){this._line=NaN},lineStart:function(){this._x=[],this._y=[]},lineEnd:function(){var t=this._x,n=this._y,e=t.length;if(e)if(this._line?this._context.lineTo(t[0],n[0]):this._context.moveTo(t[0],n[0]),2===e)this._context.lineTo(t[1],n[1]);else for(var r=gc(t),i=gc(n),o=0,u=1;u<e;++o,++u)this._context.bezierCurveTo(r[0][o],i[0][o],r[1][o],i[1][o],t[u],n[u]);(this._line||0!==this._line&&1===e)&&this._context.closePath(),this._line=1-this._line,this._x=this._y=null},point:function(t,n){this._x.push(+t),this._y.push(+n)}};mc.prototype={areaStart:function(){this._line=0},areaEnd:function(){this._line=NaN},lineStart:function(){this._x=this._y=NaN,this._point=0},lineEnd:function(){0<this._t&&this._t<1&&2===this._point&&this._context.lineTo(this._x,this._y),(this._line||0!==this._line&&1===this._point)&&this._context.closePath(),this._line>=0&&(this._t=1-this._t,this._line=1-this._line)},point:function(t,n){switch(t=+t,n=+n,this._point){case 0:this._point=1,this._line?this._context.lineTo(t,n):this._context.moveTo(t,n);break;case 1:this._point=2;default:if(this._t<=0)this._context.lineTo(this._x,n),this._context.lineTo(t,n);else{var e=this._x*(1-this._t)+t*this._t;this._context.lineTo(e,this._y),this._context.lineTo(e,n)}}this._x=t,this._y=n}};var rm=function(t,n){if((i=t.length)>1)for(var e,r,i,o=1,u=t[n[0]],a=u.length;o<i;++o)for(r=u,u=t[n[o]],e=0;e<a;++e)u[e][1]+=u[e][0]=isNaN(r[e][1])?r[e][0]:r[e][1]},im=function(t){for(var n=t.length,e=new Array(n);--n>=0;)e[n]=n;return e},om=function(t){var n=t.map(bc);return im(t).sort(function(t,e){return n[t]-n[e]})},um=function(t){return function(){return t}};Tc.prototype={constructor:Tc,insert:function(t,n){var e,r,i;if(t){if(n.P=t,n.N=t.N,t.N&&(t.N.P=n),t.N=n,t.R){for(t=t.R;t.L;)t=t.L;t.L=n}else t.R=n;e=t}else this._?(t=Ec(this._),n.P=null,n.N=t,t.P=t.L=n,e=t):(n.P=n.N=null,this._=n,e=null);for(n.L=n.R=null,n.U=e,n.C=!0,t=n;e&&e.C;)e===(r=e.U).L?(i=r.R)&&i.C?(e.C=i.C=!1,r.C=!0,t=r):(t===e.R&&(Nc(this,e),e=(t=e).U),e.C=!1,r.C=!0,Sc(this,r)):(i=r.L)&&i.C?(e.C=i.C=!1,r.C=!0,t=r):(t===e.L&&(Sc(this,e),e=(t=e).U),e.C=!1,r.C=!0,Nc(this,r)),e=t.U;this._.C=!1},remove:function(t){t.N&&(t.N.P=t.P),t.P&&(t.P.N=t.N),t.N=t.P=null;var n,e,r,i=t.U,o=t.L,u=t.R;if(e=o?u?Ec(u):o:u,i?i.L===t?i.L=e:i.R=e:this._=e,o&&u?(r=e.C,e.C=t.C,e.L=o,o.U=e,e!==u?(i=e.U,e.U=t.U,t=e.R,i.L=t,e.R=u,u.U=e):(e.U=i,i=e,t=e.R)):(r=t.C,t=e),t&&(t.U=i),!r)if(t&&t.C)t.C=!1;else{do{if(t===this._)break;if(t===i.L){if((n=i.R).C&&(n.C=!1,i.C=!0,Nc(this,i),n=i.R),n.L&&n.L.C||n.R&&n.R.C){n.R&&n.R.C||(n.L.C=!1,n.C=!0,Sc(this,n),n=i.R),n.C=i.C,i.C=n.R.C=!1,Nc(this,i),t=this._;break}}else if((n=i.L).C&&(n.C=!1,i.C=!0,Sc(this,i),n=i.L),n.L&&n.L.C||n.R&&n.R.C){n.L&&n.L.C||(n.R.C=!1,n.C=!0,Nc(this,n),n=i.L),n.C=i.C,i.C=n.L.C=!1,Sc(this,i),t=this._;break}n.C=!0,t=i,i=i.U}while(!t.C);t&&(t.C=!1)}}};var am,cm,sm,fm,lm,hm=[],pm=[],dm=1e-6,vm=1e-12;Kc.prototype={constructor:Kc,polygons:function(){var t=this.edges;return this.cells.map(function(n){var e=n.halfedges.map(function(e){return Dc(n,t[e])});return e.data=n.site.data,e})},triangles:function(){var t=[],n=this.edges;return this.cells.forEach(function(e,r){if(o=(i=e.halfedges).length)for(var i,o,u,a=e.site,c=-1,s=n[i[o-1]],f=s.left===a?s.right:s.left;++c<o;)u=f,f=(s=n[i[c]]).left===a?s.right:s.left,u&&f&&r<u.index&&r<f.index&&Jc(a,u,f)<0&&t.push([a.data,u.data,f.data])}),t},links:function(){return this.edges.filter(function(t){return t.right}).map(function(t){return{source:t.left.data,target:t.right.data}})},find:function(t,n,e){for(var r,i,o=this,u=o._found||0,a=o.cells.length;!(i=o.cells[u]);)if(++u>=a)return null;var 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| id | value | |
|---|---|---|
| B | 1 | |
| C | 1 | |
| D | 1 | |
| E | 1 |
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| { | |
| "genes": [ | |
| { | |
| "name": "Insulin", | |
| "sequence": "MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN" | |
| }, | |
| { | |
| "name": "Brca1", | |
| "sequence": "MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY" | |
| }, | |
| { | |
| "name": "Titin", | |
| "sequence": "MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQASTVATGPEVPPPWKQEGYVASSSEAEMRETTLTTSTQIRTEERWEGRYGVQEQVTISGAAGAAASVSASASYAAEAVATGAKEVKQDADKSAAVATVVAAVDMARVREPVISAVEQTAQRTTTTAVHIQPAQEQVRKEAEKTAVTKVVVAADKAKEQELKSRTKEVITTKQEQMHVTHEQIRKETEKTFVPKVVISAAKAKEQETRISEEITKKQKQVTQEAIRQETEITAASMVVVATAKSTKLETVPGAQEETTTQQDQMHLSYEKIMKETRKTVVPKVIVATPKVKEQDLVSRGREGITTKREQVQITQEKMRKEAEKTALSTIAVATAKAKEQETILRTRETMATRQEQIQVTHGKVDVGKKAEAVATVVAAVDQARVREPREPGHLEESYAQQTTLEYGYKERISAAKVAEPPQRPASEPHVVPKAVKPRVIQAPSETHIKTTDQKGMHISSQIKKTTDLTTERLVHVDKRPRTASPHFTVSKISVPKTEHGYEASIAGSAIATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQFPFADTPDTYKSEAGVEVKKEVGVSITGTTVREERFEVLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEPGKLQFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVETVKIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKINETLELLSESPVYPTKFDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAKSTPEAPEDFPQTPLKGPAVEALDSEQEIATFVKDTILKAALITEENQQLSYEHIAKANELSSQLPLGAQELQSILEQDKLTPESTREFLCINGSIHFQPLKEPSPNLQLQIVQSQKTFSKEGILMPEEPETQAVLSDTEKIFPSAMSIEQINSLTVEPLKTLLAEPEGNYPQSSIEPPMHSYLTSVAEEVLSPKEKTVSDTNREQRVTLQKQEAQSALILSQSLAEGHVESLQSPDVMISQVNYEPLVPSEHSCTEGGKILIESANPLENAGQDSAVRIEEGKSLRFPLALEEKQVLLKEEHSDNVVMPPDQIIESKREPVAIKKVQEVQGRDLLSKESLLSGIPEEQRLNLKIQICRALQAAVASEQPGLFSEWLRNIEKVEVEAVNITQEPRHIMCMYLVTSAKSVTEEVTIIIEDVDPQMANLKMELRDALCAIIYEEIDILTAEGPRIQQGAKTSLQEEMDSFSGSQKVEPITEPEVESKYLISTEEVSYFNVQSRVKYLDATPVTKGVASAVVSDEKQDESLKPSEEKEESSSESGTEEVATVKIQEAEGGLIKEDGPMIHTPLVDTVSEEGDIVHLTTSITNAKEVNWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKNVDPKEYEKYARMYGITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSFIQQRLSQTEPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLVCGPHIASAKLTVIEPAWERHLQDVTLKEGQTCTMTCQFSVPNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQFTKRIQNIVVSEHQSATFECEVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLELKPPDIPDSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELNKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREVELLKPIEDVTIYEKESASFDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFECVLTREANVIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLEGDPYFTGKLQDYTGVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFETEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPVTVKDQTCPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCDPPGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITKEDKTRAMNYDEEVDETREVSMTKASHSSTKELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQKIERVSTKVIRTLKHRRYYHTLIKKDLNMVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKKQEFKSKEEHERHVQKQIDKTLRMAEILSGTESVPLTQVAKEALREAAVLYKPAVSTKTVKGEFRLEIEEKKEERKLRMPYDVPEPRKYKQTTIEEDQRIKQFVPMSDMKWYKKIRDQYEMPGKLDRVVQKRPKRIRLSRWEQFYVMPLPRITDQYRPKWRIPKLSQDDLEIVRPARRRTPSPDYDFYYRPRRRSLGDISDEELLLPIDDYLAMKRTEEERLRLEEELELGFSASPPSRSPPHFELSSLRYSSPQAHVKVEETRKDFRYSTYHIPTKAEASTSYAELRERHAQAAYRQPKQRQRIMAEREDEELLRPVTTTQHLSEYKSELDFMSKEEKSRKKSRRQREVTEITEIEEEYEISKHAQRESSSSASRLLRRRRSLSPTYIELMRPVSELIRSRPQPAEEYEDDTERRSPTPERTRPRSPSPVSSERSLSRFERSARFDIFSRYESMKAALKTQKTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI" | |
| }, | |
| { | |
| "name": "ABO,IRF4,MC1R,SLC24A5", | |
| "sequence": "MPRDNMASLIQRIARQACLTFRGSGGGRGASDRDAASGPEAPMQPGFPENLSKLKSLLTQLRAEDLNIAPRKATLQPLPPNLPPVTYMHIYETDGFSLGVFLLKSGTSIPLHDHPGMHGMLKVLYGTVRISCMDKLDAGGGQRPRALPPEQQFEPPLQPREREAVRPGVLRSRAEYTEASGPCILTPHRDNLHQIDAVEGPAAFLDILAPPYDPDDGRDCHYYRVLEPVRPKEASSSACDLPREVWLLETPQADDFWCEGEPYPGPKVFP" | |
| } | |
| ] | |
| } |
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| <!DOCTYPE html> | |
| <script src="d3.v4.min.js"></script> | |
| <script src="nextprot.bundle.js"></script> | |
| <script src="https://cdnjs.cloudflare.com/ajax/libs/jquery-csv/0.8.3/jquery.csv.min.js"></script> | |
| <script> | |
| var colorsCategory = { | |
| "aliphatic": "yellow", // Non Polar | |
| "basic" : "orange", // Polar (non charged) | |
| "amide" : "blue", //+ negatively charged | |
| "acid": "red", //+ posively charged | |
| "sulfur-containing" : "green", | |
| "basic aromatic" : "violet", | |
| "aromatic" : "grey", | |
| "cyclic" : "cyan", | |
| "hydroxyl-containing" : "chocolate" | |
| } | |
| var arraydata; | |
| $.ajax({ type: "GET", | |
| url: "amino-acids.tsv", | |
| dataType: "text", | |
| async: false, | |
| success: function(csv) {arraydata = $.csv.toArrays(csv,{separator:'\t'}); } | |
| }); | |
| var dict = {} | |
| var header = arraydata[0] | |
| arraydata.slice(1,).forEach(function (d) { | |
| dict[d[2]] = { | |
| "fullName" : d[0], | |
| "shortName" : d[1], | |
| "oneLetterCode" : d[2], | |
| "sideChainClass" : d[3], | |
| "sideChainPolarity" : d[4], | |
| "sideChainCharge" : d[5] | |
| } | |
| }) | |
| console.log(arraydata) | |
| console.log(dict) | |
| </script> | |
| <style type="text/css"> | |
| #container { | |
| overflow-y: scroll; | |
| max-height: 800px; | |
| border-width: 1px; | |
| border-color: grey; | |
| border-style: solid; | |
| width: 550px; | |
| margin: 10px; | |
| } | |
| select { | |
| margin: 10px; | |
| } | |
| table { | |
| margin: 10px; | |
| } | |
| table tr td { | |
| border-width: 1px; | |
| border-color: grey; | |
| border-style: solid; | |
| } | |
| .aliphatic { background-color: yellow } | |
| .basic { background-color: orange } | |
| .amide { background-color: blue } | |
| .acid { background-color: red } | |
| .sulfur-containing { background-color: green } | |
| .basic-aromatic { background-color: violet } | |
| .aromatic { background-color: grey } | |
| .cyclic { background-color: cyan } | |
| .hydroxyl-containing { background-color: chocolate } | |
| </style> | |
| <body> | |
| <div> | |
| This mockup attemps to explore the feasibility of doing a kind of bubble shooting / candy crush using the side chain class. | |
| <p style="color: blue"> | |
| How to replace amino acids, with "real" ones, when completing one line or column? (To make it real) | |
| </p> | |
| </div> | |
| <div> | |
| <table> | |
| <tr> | |
| <th>Chain Class</th> | |
| </tr> | |
| <tr> | |
| <td class="aliphatic"></td> | |
| <td>aliphatic</td> | |
| </tr> | |
| <tr> | |
| <td class="basic"></td> | |
| <td>basic</td> | |
| </tr> | |
| <tr> | |
| <td class="amide"></td> | |
| <td>amide</td> | |
| </tr> | |
| <tr> | |
| <td class="acid"></td> | |
| <td>acid</td> | |
| </tr> | |
| <tr> | |
| <td class="sulfur-containing"></td> | |
| <td>sulfur-containing</td> | |
| </tr> | |
| <tr> | |
| <td class="basic-aromatic"></td> | |
| <td>basic-aromatic</td> | |
| </tr> | |
| <tr> | |
| <td class="aromatic"></td> | |
| <td>aromatic</td> | |
| </tr> | |
| <tr> | |
| <td class="cyclic"></td> | |
| <td>cyclic</td> | |
| </tr> | |
| <tr> | |
| <td class="hydroxyl-containing"></td> | |
| <td>hydroxyl-containing</td> | |
| </tr> | |
| </table> | |
| </div> | |
| <div> | |
| <select class="target"> | |
| <option selected="">Select Your Protein</option> | |
| <option value="P01308">Insulin (related to diabetes) #110</option> | |
| <option value="P68871">HBB (hemoglobine) Ch11 #147</option> | |
| <option value="Q01726">MC1R (cheveux roux) #Ch16 317</option> | |
| <option value="P16442">ABO (blood) #354</option> | |
| <option value="P38398">Breast Cancer #1863</option> | |
| <option value="O95714">HERC2 (mutant responsible for the eye color) #4834</option> | |
| <option value="Q15306">IRF4 (hair color) #451</option> | |
| <option value="Q71RS6">Q71RS6 (clear skin) #500</option> | |
| <option value="Q9H4L7">SMARCAD1 (no fingerprints) Ch4 #11026</option> | |
| <option value="Q08043">ACTN3 (more muscle powers) Ch11 #901</option> | |
| <option value="P10275">AR (calivitie) ChX #920</option> | |
| </select> | |
| <input id="accession"></input> | |
| <button id="loadButton" type="submit">Load</button> | |
| <div> | |
| <div style="margin: 10px"> | |
| <span id="nRows"></span> | |
| </div> | |
| <div id="container"> | |
| <svg id="canva" width="960" height="20000" font-family="sans-serif" font-size="10" text-anchor="middle"></svg> | |
| </div> | |
| </body> | |
| <script> | |
| var nBallsPerLine = 10 | |
| var applicationName = 'game-test'; //please provide a name for your application | |
| var clientInfo='gist'; //please provide some information about you | |
| var nx = new Nextprot.Client(applicationName, clientInfo); | |
| $( ".target" ).change(function() { | |
| $('#accession').val(this.value); | |
| loadProtein() | |
| }) | |
| $("#loadButton").click(function() { | |
| loadProtein() | |
| }); | |
| function loadProtein () { | |
| //Clearing | |
| d3.select("#canva").selectAll("*").remove() | |
| $("#nRows").text("") | |
| accession = $('#accession').val(); | |
| nx.getEntry('NX_' + accession, "secondary-structure").then(function (data){ | |
| var sequence = data.isoforms[0].sequence; | |
| var aminoAcids = sequence.split("").reverse() | |
| $("#nRows").html("Rows:" + (aminoAcids.length / nBallsPerLine) + " amino acid length:" + aminoAcids.length + " more info in nextprot: <a target=\"blank\" href=\"https://www.nextprot.org/entry/NX_"+ accession + " \"/sequence>NX_" + accession + "</a> or UniProt <a target=\"blank\" href=\"http://www.uniprot.org/uniprot/"+ accession + " \">" + accession + "</a> ") | |
| var svg = d3.select("#canva"), width = +svg.attr("width"), height = +svg.attr("height"); | |
| var format = d3.format(",d"); | |
| var color = d3.scaleOrdinal(d3.schemeCategory10); | |
| var pack = d3.pack().size([width, height]).padding(1.5); | |
| var i= 0; | |
| d3.request("genes.json") | |
| .mimeType("application/json") | |
| .response(function(xhr) { | |
| return JSON.parse(xhr.responseText); | |
| }).get(function (data) { | |
| var aas = aminoAcids.map(function (a){ return { | |
| "i" : i++, | |
| "id" : a, | |
| "value": dict[a].MW, | |
| "package": dict[a].sideChainClass, | |
| "class": dict[a].oneLetterCode + "-" + dict[a].shortName // "\n" + i++ | |
| }}) | |
| var group = svg.selectAll('circle').data(aas).enter().append("g") | |
| .attr("transform", function(d,i){ | |
| return "translate("+((i%nBallsPerLine)*45+50)+","+(~~(i/nBallsPerLine)*45 + 50)+")" | |
| }); | |
| group.append('circle').attr("r", 20).attr("fill", function(d,i){ | |
| return colorsCategory[d.package]}); | |
| group.append('text').text(function(d){return d.class}) | |
| }); | |
| }); | |
| } | |
| </script> |
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| <!DOCTYPE html> | |
| <script src="https://cdn.rawgit.com/calipho-sib/feature-viewer/v1.0.0/dist/feature-viewer.nextprot.js"></script> | |
| <style type="text/css"> | |
| #container { | |
| overflow-y: scroll; | |
| max-height: 800px; | |
| border-width: 1px; | |
| border-color: grey; | |
| border-style: solid; | |
| width: 1200px; | |
| margin: 10px; | |
| } | |
| select { | |
| margin: 10px; | |
| } | |
| table { | |
| margin: 10px; | |
| } | |
| table tr td { | |
| border-width: 1px; | |
| border-color: grey; | |
| border-style: solid; | |
| } | |
| </style> | |
| <body> | |
| <div> | |
| This mockup attemps to explore the feasibility of doing a kind of runner like Super Mario World or even Rider Ketchapp. | |
| </div> | |
| <div> | |
| <select class="target"> | |
| <option selected="">Select Your Protein</option> | |
| <option value="P01308">Insulin (related to diabetes) Chromosome 11 #2 exons easy!</option> | |
| <option value="P68871">HBB (hemoglobine) Chromosome 11 #3 exons</option> | |
| <option value="P10275">AR (calivitie) Chromosome X #8 exons</option> | |
| <option value="Q15306">IRF4 (hair color) Chromosome 6 #9 exons</option> | |
| <option value="Q71RS6">Q71RS6 (clear skin) Chromsome 15 #500</option> | |
| <option value="Q9H4L7">SMARCAD1 (no fingerprints) Ch4 #24 exons</option> | |
| <option value="Q08043">ACTN3 (more muscle powers) Ch11 #21 exons</option> | |
| <option value="P38398">Breast Cancer Chromsome 17 #23 exons</option> | |
| <option value="O95714">HERC2 (mutant responsible for the eye color) #93 exons (super complicated level)</option> | |
| </select> | |
| <input id="accession"></input> | |
| <button id="loadButton" type="submit">Load</button> | |
| <div> | |
| <div style="margin: 10px"> | |
| <span id="nRows"></span> | |
| </div> | |
| <div id="container"> | |
| <div id="div2" style="width:1024px;height:480px" ></div> | |
| </div> | |
| <img src="https://i.ytimg.com/vi/3DSFPrZN-Sw/hqdefault.jpg"></img> | |
| <img src="https://i.ytimg.com/vi/L5aA95nYO_0/hqdefault.jpg"></img> | |
| <p style="color: blue"> | |
| Proposed rules (can be changed... ):<br> | |
| <ul> | |
| <li>Need to jump over all exons (can be a avatar, can be a fish swimming in a water pipe, there may be physics involved for the gravity...)</li> | |
| <li>Need to avoid some bad variants related to cancer. </li> | |
| <li>There is a SUPER variant in each level that he must get for example to have blue eyes, or red hair. Otherwiser the level is completed without the super bonus....</li> | |
| </ul> | |
| </p> | |
| <p style="color: blue"> | |
| To think about...<br> | |
| <ul> | |
| <li>Still need to place the variants to check their positions in the world </li> | |
| </ul> | |
| </p> | |
| <p style="color: green"> | |
| Strenght: | |
| <ul> | |
| <li>Can be very addictive and with stories at each level about the SUPER variant</li> | |
| </ul> | |
| </p> | |
| <p style="color: red"> | |
| Weaknesses: | |
| <ul> | |
| </ul> | |
| </p> | |
| </body> | |
| <script> | |
| var nBallsPerLine = 10 | |
| var applicationName = 'game-test'; //please provide a name for your application | |
| var clientInfo='gist'; //please provide some information about you | |
| var nx = new Nextprot.Client(applicationName, clientInfo); | |
| $( ".target" ).change(function() { | |
| $('#accession').val(this.value); | |
| loadProtein() | |
| }) | |
| $("#loadButton").click(function() { | |
| loadProtein() | |
| }); | |
| function getBaseLog(x, y) { | |
| return Math.log(y) / Math.log(x); | |
| } | |
| function normalizeLength(exonIntron) { | |
| var length = exonIntron.y - exonIntron.x; | |
| var normalizedLength = length; | |
| console.log("-----") | |
| if(exonIntron.type == "intron"){ | |
| console.log("Max Intron: " , maxLIntron) | |
| normalizedLength = Math.floor((20 * length / maxLIntron)) + 10 | |
| }else if(exonIntron.type == "exon"){ | |
| console.log("Max Exon: " , maxLExon) | |
| normalizedLength = Math.floor((100 * length / maxLExon)) + 30 | |
| } | |
| console.log("Real length: " , length) | |
| console.log("normalizedLength: " , normalizedLength) | |
| exonIntron.description = exonIntron.description + ", normalizedLength : " + normalizedLength | |
| exonIntron.y = exonIntron.x + normalizedLength | |
| return exonIntron | |
| } | |
| function removeHoles (exonsAndIntrons) { | |
| var newExonsIntrons = [] | |
| for(var i=0; i<exonsAndIntrons.length; i++){ | |
| var ei = exonsAndIntrons[i] | |
| if(i+1<exonsAndIntrons.length){ | |
| var nextei = exonsAndIntrons[i+1] | |
| var nextlenght = nextei.y - nextei.x | |
| nextei.x = ei.y | |
| nextei.y = nextei.x + nextlenght | |
| } | |
| newExonsIntrons.push(ei) | |
| } | |
| return newExonsIntrons; | |
| } | |
| //Terrible hack !!! | |
| var maxLIntron = -1; | |
| var maxLExon = -1; | |
| function normalizeExonsAndIntrons (exonsAndIntrons) { | |
| var intron = exonsAndIntrons.filter(function(e) {return e.type === "intron"}) | |
| var exons = exonsAndIntrons.filter(function(e) {return e.type === "exon"}) | |
| intron.forEach(function(e) { if((e.y - e.x) > maxLIntron){ maxLIntron = (e.y - e.x);}}) | |
| exons.forEach(function(e) { if((e.y - e.x) > maxLExon){ maxLExon = (e.y - e.x); }}) | |
| console.log("Max Intron: " + maxLIntron) | |
| console.log("Max Exon: " + maxLExon) | |
| var exonsAndIntronsNormalized = exonsAndIntrons.map(normalizeLength) | |
| return exonsAndIntronsNormalized; | |
| } | |
| function renderTranscript (transcript) { | |
| var transcriptAccession = transcript.accession | |
| var exons = transcript.exons | |
| $("#nRows").html("Exons count:" + exons.length + " more info in nextprot: <a target=\"blank\" href=\"https://www.nextprot.org/entry/NX_"+ accession + "/exons\">NX_" + accession + "</a>") | |
| var maxLength = -1; | |
| var minLength = Number.MAX_SAFE_INTEGER; | |
| var exons = exons.map(function(e) { | |
| var endPos = e.lastPositionOnGene; | |
| var startPos = e.firstPositionOnGene; | |
| console.log(endPos) | |
| console.log(startPos) | |
| if(endPos > maxLength){ | |
| maxLength = endPos; | |
| } | |
| if(startPos < minLength){ | |
| minLength = startPos; | |
| } | |
| var offset = minLength - 10; | |
| return { | |
| "x": startPos - offset, | |
| "y": endPos - offset, | |
| "description": e.accession + ". Real size: " + (endPos - startPos), | |
| "type" : "exon", | |
| "id" : e.accession, | |
| "color" : "green", | |
| "height" : "2px" | |
| } | |
| }) | |
| var exonsAndIntrons = []; | |
| for(var i=0; i<exons.length; i++){ | |
| var exon = exons[i]; | |
| exonsAndIntrons.push(exon) | |
| if(i+1 < exons.length) { | |
| var nextexon = exons[i+1]; | |
| var intron = { | |
| "x": exon.y + 1, | |
| "y": nextexon.x - 1, | |
| "description": "intron. Real size: " + (nextexon.x - exon.y) , | |
| "id" : "intron", | |
| "color" : "red", | |
| "type" : "intron", | |
| "height" : 4 | |
| } | |
| exonsAndIntrons.push(intron) | |
| } | |
| } | |
| exonsAndIntronsNormalized = removeHoles(normalizeExonsAndIntrons(exonsAndIntrons)) | |
| var maxLength = -1; | |
| var minLength = Number.MAX_SAFE_INTEGER; | |
| var exons = exonsAndIntronsNormalized.forEach(function(e) { | |
| var startPos = e.x; | |
| var endPos = e.y; | |
| if(endPos > maxLength){ maxLength = endPos;} | |
| if(startPos < minLength){ minLength = startPos;} | |
| }) | |
| //Create a new Feature Viewer and add some rendering options | |
| var ft2 = new FeatureViewer(maxLength + 20,"#div2", | |
| { showAxis: true, | |
| showSequence: true, | |
| brushActive: true, | |
| toolbar:true, | |
| bubbleHelp:true, | |
| zoomMax:10}); | |
| //Add some features | |
| ft2.addFeature({ | |
| data: exonsAndIntrons, | |
| name: transcriptAccession, | |
| className: "test1", | |
| color: "#005572", | |
| type: "rect", | |
| filter: "type1" | |
| }); | |
| function getRandomArbitrary(min, max) { | |
| return Math.floor(Math.random() * (max - min) + min); | |
| } | |
| function getNumber (x){ | |
| for (var i=0; i<exonsAndIntrons.length; i++){ | |
| var ei = exonsAndIntrons[i]; | |
| if(x >= ei.x && x <= ei.y){ | |
| if(ei.type == "exon") | |
| return getRandomArbitrary((40), (50 + i)) | |
| else if(ei.type == "intron") | |
| return - getRandomArbitrary(40, 50) ; | |
| } | |
| } | |
| return 0 | |
| } | |
| var dataDemo = []; | |
| for (var i=1;i<maxLength;i+=2) { | |
| var x = i*2; | |
| dataDemo.push({ x: x, y: getNumber(x)}) | |
| } | |
| ft2.addFeature({ | |
| data: dataDemo, | |
| name: "terrain", | |
| className: "test5", | |
| color: "#008B8D", | |
| type: "line", | |
| filter: "type2", | |
| height: "5" | |
| }); | |
| } | |
| function loadProtein () { | |
| $( "#div2" ).empty(); | |
| //Terrible hack !!! | |
| var maxLIntron = -1; | |
| var maxLExon = -1; | |
| $("#nRows").text("") | |
| accession = $('#accession').val(); | |
| nx.getEntry('NX_' + accession).then(function (data){ | |
| data.genomicMappings.forEach(function (gm) { | |
| gm.isoformMappings.forEach(function (im) { | |
| im.transcriptMappings.forEach(function (t) { | |
| renderTranscript(t) | |
| }) | |
| }) | |
| }) | |
| })} | |
| </script> |
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| <!DOCTYPE html> | |
| <script src="d3.v4.min.js"></script> | |
| <script src="nextprot.bundle.js"></script> | |
| <script src="https://cdnjs.cloudflare.com/ajax/libs/jquery-csv/0.8.3/jquery.csv.min.js"></script> | |
| <script> | |
| var colorsCategory = { | |
| "nonpolar": " #008744", // Non Polar | |
| "polar" : "#0057e7", // Polar (non charged) | |
| "acidic polar" : "#d62d20", //+ negatively charged | |
| "basic polar": "#ffa700", //+ posively charged | |
| "helix" : "grey" | |
| } | |
| var arraydata; | |
| $.ajax({ type: "GET", | |
| url: "amino-acids.tsv", | |
| dataType: "text", | |
| async: false, | |
| success: function(csv) {arraydata = $.csv.toArrays(csv,{separator:'\t'}); } | |
| }); | |
| var dict = {} | |
| var header = arraydata[0] | |
| arraydata.slice(1,).forEach(function (d) { | |
| dict[d[2]] = { | |
| "fullName" : d[0], | |
| "shortName" : d[1], | |
| "oneLetterCode" : d[2], | |
| "sideChainClass" : d[3], | |
| "sideChainPolarity" : d[4], | |
| "sideChainCharge" : d[5], | |
| } | |
| }) | |
| console.log(arraydata) | |
| console.log(dict) | |
| </script> | |
| <style type="text/css"> | |
| #container { | |
| overflow-y: scroll; | |
| max-height: 800px; | |
| border-width: 1px; | |
| border-color: grey; | |
| border-style: solid; | |
| width: 550px; | |
| margin: 10px; | |
| } | |
| select { | |
| margin: 10px; | |
| } | |
| table { | |
| margin: 10px; | |
| } | |
| table tr td { | |
| border-width: 1px; | |
| border-color: grey; | |
| border-style: solid; | |
| } | |
| /* Green */ | |
| .nonpolar { | |
| background-color: #008744 | |
| } | |
| /* Blue */ | |
| .polar { | |
| background-color: #0057e7 | |
| } | |
| /* Blue */ | |
| .acid-polar { | |
| background-color: #d62d20 | |
| } | |
| /* Blue */ | |
| .basic-polar { | |
| background-color: #ffa700 | |
| } | |
| </style> | |
| <body> | |
| <div> | |
| This mockup attemps to explore the feasibility of doing a kind of bubble shooting / candy crush / ballz using the polar group of the amino acids of real sequences. | |
| </div> | |
| <div> | |
| <table> | |
| <tr> | |
| <th>Color</th> | |
| <th>Group</th> | |
| <th>Characteristics</th> | |
| <th>Names</th> | |
| </tr> | |
| <tr> | |
| <td class="nonpolar"></td> | |
| <td>non-polar</td> | |
| <td>hydrophobic</td> | |
| <td>Ala, Val, Leu, Ile, Pro, Phe, Trp, Met</td> | |
| </tr> | |
| <tr> | |
| <td class="polar"></td> | |
| <td>polar</td> | |
| <td>hydrophilic (non-charged)</td> | |
| <td>Gly, Ser, Thr, Cys, Tyr, Asn, Gln</td> | |
| </tr> | |
| <tr> | |
| <td class="acid-polar"></td> | |
| <td>acidic</td> | |
| <td>negatively-charged</td> | |
| <td>Asp, Glu</td> | |
| </tr> | |
| <tr> | |
| <td class="basic-polar"></td> | |
| <td>basic</td> | |
| <td>positively-charged</td> | |
| <td>Lys, Arg, His</td> | |
| </tr> | |
| </table> | |
| </div> | |
| <div> | |
| <select class="target"> | |
| <option selected="">Select Your Protein</option> | |
| <option value="P01308">Insulin (related to diabetes) #110</option> | |
| <option value="P68871">HBB (hemoglobine) Ch11 #147</option> | |
| <option value="Q01726">MC1R (cheveux roux) #Ch16 317</option> | |
| <option value="P16442">ABO (blood) #354</option> | |
| <option value="P38398">Breast Cancer #1863</option> | |
| <option value="O95714">HERC2 (mutant responsible for the eye color) #4834</option> | |
| <option value="Q15306">IRF4 (hair color) #451</option> | |
| <option value="Q71RS6">Q71RS6 (clear skin) #500</option> | |
| <option value="Q9H4L7">SMARCAD1 (no fingerprints) Ch4 #11026</option> | |
| <option value="Q08043">ACTN3 (more muscle powers) Ch11 #901</option> | |
| <option value="P10275">AR (calivitie) ChX #920</option> | |
| </select> | |
| <input id="accession"></input> | |
| <button id="loadButton" type="submit">Load</button> | |
| <div> | |
| <div style="margin: 10px"> | |
| <span id="nRows"></span> | |
| </div> | |
| <div id="container"> | |
| <svg id="canva" width="960" height="20000" font-family="sans-serif" font-size="10" text-anchor="middle"></svg> | |
| </div> | |
| <div> | |
| <select id="firstCodon" class="base"> | |
| <option value="U">U</option> | |
| <option value="C">C</option> | |
| <option value="A">A</option> | |
| <option value="G">G</option> | |
| </select> | |
| <select id="secondCodon" class="base"> | |
| <option value="U">U</option> | |
| <option value="C">C</option> | |
| <option value="A">A</option> | |
| <option value="G">G</option> | |
| </select> | |
| <select id="thirdCodon" class="base"> | |
| <option value="U">U</option> | |
| <option value="C">C</option> | |
| <option value="A">A</option> | |
| <option value="G">G</option> | |
| </select> | |
| <span id="aminoAcid"></span> | |
| <svg id="bubble" width="100" height="50" font-family="sans-serif" font-size="10" text-anchor="middle"></svg> | |
| <div> | |
| <p style="color: blue"> | |
| Proposed rules (can be changed... ):<br> | |
| <ul> | |
| <li>When shooting the correct color (not the same amino acid) only the shot bubble disappears</li> | |
| <li>When shooting the correct amino acid (not only the color) everything adjacent with the same color falls down</li> | |
| <li>When shooting an amino acid with different color it stays stuck</li> | |
| </ul> | |
| </p> | |
| <p style="color: blue"> | |
| To think about...<br> | |
| <ul> | |
| <li>Some proteins like HBB has too many green (non polar) amino acids, and therefore it is easy to finish the level with just one shot. We may need to introduce some kind of shields between adjacent proteins. Could be helixes annotations or other thing...</li> | |
| </ul> | |
| </p> | |
| <p style="color: green"> | |
| Strenght: | |
| <ul> | |
| <li>People get to know amino acids and their polarity</li> | |
| <li>People get to know translation</li> | |
| </ul> | |
| </p> | |
| <p style="color: red"> | |
| Weaknesses: | |
| <ul> | |
| <li>Not enough dynamic? (Too much thinking?) May be boring....</li> | |
| <li>People may think a protein is like a "collier de perle"</li> | |
| </ul> | |
| </p> | |
| </body> | |
| <script> | |
| var nBallsPerLine = 10 | |
| var applicationName = 'game-test'; //please provide a name for your application | |
| var clientInfo='gist'; //please provide some information about you | |
| var nx = new Nextprot.Client(applicationName, clientInfo); | |
| $( ".base" ).change(function() { | |
| $( "#bubble" ).empty(); | |
| var codons = $('#firstCodon').val() + $('#secondCodon').val() + $('#thirdCodon').val() | |
| var aminoAcid = "Not defined" | |
| if(codons === "UUU") aminoAcid = "F" | |
| else if(codons === "UUC") aminoAcid = "F" | |
| else if(codons === "UUA") aminoAcid = "L" | |
| else if(codons === "UUG") aminoAcid = "L" | |
| else if(codons === "CUU") aminoAcid = "L" | |
| else if(codons === "CUC") aminoAcid = "L" | |
| else if(codons === "CUG") aminoAcid = "L" | |
| else if(codons === "AUU") aminoAcid = "I" | |
| else if(codons === "AUC") aminoAcid = "I" | |
| else if(codons === "AUA") aminoAcid = "I" | |
| else if(codons === "AUG") aminoAcid = "M" | |
| else if(codons === "GUU") aminoAcid = "V" | |
| else if(codons === "GUC") aminoAcid = "V" | |
| else if(codons === "GUA") aminoAcid = "V" | |
| else if(codons === "GUG") aminoAcid = "V" | |
| else if(codons === "UCU") aminoAcid = "S" | |
| else if(codons === "UCC") aminoAcid = "S" | |
| else if(codons === "UCA") aminoAcid = "S" | |
| else if(codons === "UCG") aminoAcid = "S" | |
| else if(codons === "CCU") aminoAcid = "P" | |
| else if(codons === "CCC") aminoAcid = "P" | |
| else if(codons === "CCA") aminoAcid = "P" | |
| else if(codons === "CCG") aminoAcid = "P" | |
| else if(codons === "ACU") aminoAcid = "T" | |
| else if(codons === "ACC") aminoAcid = "T" | |
| else if(codons === "ACA") aminoAcid = "T" | |
| else if(codons === "ACG") aminoAcid = "T" | |
| else if(codons === "GCU") aminoAcid = "A" | |
| else if(codons === "GCC") aminoAcid = "A" | |
| else if(codons === "GCA") aminoAcid = "A" | |
| else if(codons === "GCG") aminoAcid = "A" | |
| else if(codons === "UAU") aminoAcid = "T" | |
| else if(codons === "UAC") aminoAcid = "T" | |
| else if(codons === "UAA") aminoAcid = "STOP" | |
| else if(codons === "UAG") aminoAcid = "STOP" | |
| else if(codons === "CAU") aminoAcid = "H" | |
| else if(codons === "CAC") aminoAcid = "H" | |
| else if(codons === "CAA") aminoAcid = "Q" | |
| else if(codons === "CAG") aminoAcid = "Q" | |
| else if(codons === "AAU") aminoAcid = "N" | |
| else if(codons === "AAC") aminoAcid = "N" | |
| else if(codons === "AAA") aminoAcid = "K" | |
| else if(codons === "AAG") aminoAcid = "K" | |
| else if(codons === "GAU") aminoAcid = "D" | |
| else if(codons === "GAC") aminoAcid = "D" | |
| else if(codons === "GAA") aminoAcid = "E" | |
| else if(codons === "GAG") aminoAcid = "E" | |
| else if(codons === "UGU") aminoAcid = "C" | |
| else if(codons === "UGC") aminoAcid = "C" | |
| else if(codons === "UGA") aminoAcid = "STOP" | |
| else if(codons === "UGG") aminoAcid = "W" | |
| else if(codons === "CGU") aminoAcid = "R" | |
| else if(codons === "CGC") aminoAcid = "R" | |
| else if(codons === "CGA") aminoAcid = "R" | |
| else if(codons === "CGG") aminoAcid = "R" | |
| else if(codons === "AGU") aminoAcid = "S" | |
| else if(codons === "AGC") aminoAcid = "S" | |
| else if(codons === "AGA") aminoAcid = "R" | |
| else if(codons === "AGG") aminoAcid = "R" | |
| else if(codons === "GGU") aminoAcid = "G" | |
| else if(codons === "GGC") aminoAcid = "G" | |
| else if(codons === "GGA") aminoAcid = "G" | |
| else if(codons === "GGG") aminoAcid = "G" | |
| $("#aminoAcid").text("You can shoot a " + aminoAcid) | |
| if(aminoAcid !== "STOP") { | |
| var aa = dict[aminoAcid].sideChainPolarity | |
| var svg = d3.select("#bubble"), width = +svg.attr("width"), height = +svg.attr("height"); | |
| var group = svg.selectAll('circle').data([1]).enter().append("g") | |
| .attr("transform", function(d,i){ return "translate("+((i%1)*45+25)+","+(~~(i/1)*45 + 25)+")"}); | |
| group.append('circle').attr("r", 20).attr("fill", function(d,i){ return colorsCategory[aa]}); | |
| group.append('text').text(function(d){ return aminoAcid}) | |
| } | |
| }) | |
| $( ".target" ).change(function() { | |
| $('#accession').val(this.value); | |
| loadProtein() | |
| }) | |
| $("#loadButton").click(function() { | |
| loadProtein() | |
| }); | |
| function loadProtein () { | |
| //Clearing | |
| d3.select("#canva").selectAll("*").remove() | |
| $("#nRows").text("") | |
| accession = $('#accession').val(); | |
| nx.getEntry('NX_' + accession, "secondary-structure").then(function (data){ | |
| var sequence = data.isoforms[0].sequence; | |
| var aminoAcids = sequence.split("").reverse() | |
| $("#nRows").html("Rows:" + (aminoAcids.length / nBallsPerLine) + " amino acid length:" + aminoAcids.length + " more info in nextprot: <a target=\"blank\" href=\"https://www.nextprot.org/entry/NX_"+ accession + " \"/sequence>NX_" + accession + "</a> or UniProt <a target=\"blank\" href=\"http://www.uniprot.org/uniprot/"+ accession + " \">" + accession + "</a> ") | |
| var svg = d3.select("#canva"), width = +svg.attr("width"), height = +svg.attr("height"); | |
| var format = d3.format(",d"); | |
| var color = d3.scaleOrdinal(d3.schemeCategory10); | |
| var pack = d3.pack().size([width, height]).padding(1.5); | |
| var i= 0; | |
| d3.request("genes.json") | |
| .mimeType("application/json") | |
| .response(function(xhr) { | |
| return JSON.parse(xhr.responseText); | |
| }).get(function (data) { | |
| var aas = aminoAcids.map(function (a){ return { | |
| "i" : i++, | |
| "id" : a, | |
| "value": dict[a].MW, | |
| "package": (false && ((i >= 33 && i <= 43) || (i >= 44 && i < 46) || (i >= 79 && i < 81))) ? "helix" : dict[a].sideChainPolarity, | |
| "class": dict[a].oneLetterCode + "-" + dict[a].shortName // "\n" + i++ | |
| }}) | |
| var group = svg.selectAll('circle').data(aas).enter().append("g") | |
| .attr("transform", function(d,i){ | |
| var lineNumber = ~~(i/nBallsPerLine) | |
| if(lineNumber % 2){ | |
| return "translate("+((i%nBallsPerLine)*45+50)+","+(~~(i/nBallsPerLine)*45 + 50)+")" | |
| } | |
| else { | |
| return "translate("+((i%nBallsPerLine)*45+70)+","+(~~(i/nBallsPerLine)*45 + 50)+")"} | |
| } | |
| ); | |
| group.append('circle').attr("r", 20).attr("fill", function(d,i){ return colorsCategory[d.package]}); | |
| group.append('text').text(function(d){return d.class}) | |
| }); | |
| }); | |
| } | |
| </script> |
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16:this.$={path:f[h-4],params:f[h-3],hash:f[h-2],blockParams:f[h-1],strip:d.stripFlags(f[h-5],f[h])};break;case 17:this.$={strip:d.stripFlags(f[h-1],f[h-1]),program:f[h]};break;case 18:var i=d.prepareBlock(f[h-2],f[h-1],f[h],f[h],!1,this._$),j=new d.Program([i],null,{},d.locInfo(this._$));j.chained=!0,this.$={strip:f[h-2].strip,program:j,chain:!0};break;case 19:this.$=f[h];break;case 20:this.$={path:f[h-1],strip:d.stripFlags(f[h-2],f[h])};break;case 21:this.$=d.prepareMustache(f[h-3],f[h-2],f[h-1],f[h-4],d.stripFlags(f[h-4],f[h]),this._$);break;case 22:this.$=d.prepareMustache(f[h-3],f[h-2],f[h-1],f[h-4],d.stripFlags(f[h-4],f[h]),this._$);break;case 23:this.$=new d.PartialStatement(f[h-3],f[h-2],f[h-1],d.stripFlags(f[h-4],f[h]),d.locInfo(this._$));break;case 24:this.$=f[h];break;case 25:this.$=f[h];break;case 26:this.$=new d.SubExpression(f[h-3],f[h-2],f[h-1],d.locInfo(this._$));break;case 27:this.$=new d.Hash(f[h],d.locInfo(this._$));break;case 28:this.$=new d.HashPair(d.id(f[h-2]),f[h],d.locInfo(this._$));break;case 29:this.$=d.id(f[h-1]);break;case 30:this.$=f[h];break;case 31:this.$=f[h];break;case 32:this.$=new d.StringLiteral(f[h],d.locInfo(this._$));break;case 33:this.$=new d.NumberLiteral(f[h],d.locInfo(this._$));break;case 34:this.$=new d.BooleanLiteral(f[h],d.locInfo(this._$));break;case 35:this.$=new d.UndefinedLiteral(d.locInfo(this._$));break;case 36:this.$=new d.NullLiteral(d.locInfo(this._$));break;case 37:this.$=f[h];break;case 38:this.$=f[h];break;case 39:this.$=d.preparePath(!0,f[h],this._$);break;case 40:this.$=d.preparePath(!1,f[h],this._$);break;case 41:f[h-2].push({part:d.id(f[h]),original:f[h],separator:f[h-1]}),this.$=f[h-2];break;case 42:this.$=[{part:d.id(f[h]),original:f[h]}];break;case 43:this.$=[];break;case 44:f[h-1].push(f[h]);break;case 45:this.$=[];break;case 46:f[h-1].push(f[h]);break;case 53:this.$=[];break;case 54:f[h-1].push(f[h]);break;case 59:this.$=[];break;case 60:f[h-1].push(f[h]);break;case 65:this.$=[];break;case 66:f[h-1].push(f[h]);break;case 73:this.$=[];break;case 74:f[h-1].push(f[h]);break;case 77:this.$=[];break;case 78:f[h-1].push(f[h]);break;case 81:this.$=[];break;case 82:f[h-1].push(f[h]);break;case 85:this.$=[];break;case 86:f[h-1].push(f[h]);break;case 89:this.$=[f[h]];break;case 90:f[h-1].push(f[h]);break;case 91:this.$=[f[h]];break;case 92:f[h-1].push(f[h])}},table:[{3:1,4:2,5:[2,43],6:3,13:[2,43],14:[2,43],17:[2,43],27:[2,43],32:[2,43],46:[2,43],49:[2,43],53:[2,43]},{1:[3]},{5:[1,4]},{5:[2,2],7:5,8:6,9:7,10:8,11:9,12:10,13:[1,11],14:[1,18],15:16,17:[1,21],22:14,25:15,27:[1,19],32:[1,20],37:[2,2],42:[2,2],45:[2,2],46:[1,12],49:[1,13],53:[1,17]},{1:[2,1]},{5:[2,44],13:[2,44],14:[2,44],17:[2,44],27:[2,44],32:[2,44],37:[2,44],42:[2,44],45:[2,44],46:[2,44],49:[2,44],53:[2,44]},{5:[2,3],13:[2,3],14:[2,3],17:[2,3],27:[2,3],32:[2,3],37:[2,3],42:[2,3],45:[2,3],46:[2,3],49:[2,3],53:[2,3]},{5:[2,4],13:[2,4],14:[2,4],17:[2,4],27:[2,4],32:[2,4],37:[2,4],42:[2,4],45:[2,4],46:[2,4],49:[2,4],53:[2,4]},{5:[2,5],13:[2,5],14:[2,5],17:[2,5],27:[2,5],32:[2,5],37:[2,5],42:[2,5],45:[2,5],46:[2,5],49:[2,5],53:[2,5]},{5:[2,6],13:[2,6],14:[2,6],17:[2,6],27:[2,6],32:[2,6],37:[2,6],42:[2,6],45:[2,6],46:[2,6],49:[2,6],53:[2,6]},{5:[2,7],13:[2,7],14:[2,7],17:[2,7],27:[2,7],32:[2,7],37:[2,7],42:[2,7],45:[2,7],46:[2,7],49:[2,7],53:[2,7]},{5:[2,8],13:[2,8],14:[2,8],17:[2,8],27:[2,8],32:[2,8],37:[2,8],42:[2,8],45:[2,8],46:[2,8],49:[2,8],53:[2,8]},{18:22,66:[1,32],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{18:33,66:[1,32],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{4:34,6:3,13:[2,43],14:[2,43],17:[2,43],27:[2,43],32:[2,43],37:[2,43],42:[2,43],45:[2,43],46:[2,43],49:[2,43],53:[2,43]},{4:35,6:3,13:[2,43],14:[2,43],17:[2,43],27:[2,43],32:[2,43],42:[2,43],45:[2,43],46:[2,43],49:[2,43],53:[2,43]},{12:36,14:[1,18]},{18:38,54:37,58:39,59:[1,40],66:[1,32],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{5:[2,9],13:[2,9],14:[2,9],16:[2,9],17:[2,9],27:[2,9],32:[2,9],37:[2,9],42:[2,9],45:[2,9],46:[2,9],49:[2,9],53:[2,9]},{18:41,66:[1,32],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{18:42,66:[1,32],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{18:43,66:[1,32],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{31:[2,73],47:44,59:[2,73],66:[2,73],74:[2,73],75:[2,73],76:[2,73],77:[2,73],78:[2,73],79:[2,73]},{21:[2,30],31:[2,30],52:[2,30],59:[2,30],62:[2,30],66:[2,30],69:[2,30],74:[2,30],75:[2,30],76:[2,30],77:[2,30],78:[2,30],79:[2,30]},{21:[2,31],31:[2,31],52:[2,31],59:[2,31],62:[2,31],66:[2,31],69:[2,31],74:[2,31],75:[2,31],76:[2,31],77:[2,31],78:[2,31],79:[2,31]},{21:[2,32],31:[2,32],52:[2,32],59:[2,32],62:[2,32],66:[2,32],69:[2,32],74:[2,32],75:[2,32],76:[2,32],77:[2,32],78:[2,32],79:[2,32]},{21:[2,33],31:[2,33],52:[2,33],59:[2,33],62:[2,33],66:[2,33],69:[2,33],74:[2,33],75:[2,33],76:[2,33],77:[2,33],78:[2,33],79:[2,33]},{21:[2,34],31:[2,34],52:[2,34],59:[2,34],62:[2,34],66:[2,34],69:[2,34],74:[2,34],75:[2,34],76:[2,34],77:[2,34],78:[2,34],79:[2,34]},{21:[2,35],31:[2,35],52:[2,35],59:[2,35],62:[2,35],66:[2,35],69:[2,35],74:[2,35],75:[2,35],76:[2,35],77:[2,35],78:[2,35],79:[2,35]},{21:[2,36],31:[2,36],52:[2,36],59:[2,36],62:[2,36],66:[2,36],69:[2,36],74:[2,36],75:[2,36],76:[2,36],77:[2,36],78:[2,36],79:[2,36]},{21:[2,40],31:[2,40],52:[2,40],59:[2,40],62:[2,40],66:[2,40],69:[2,40],74:[2,40],75:[2,40],76:[2,40],77:[2,40],78:[2,40],79:[2,40],81:[1,45]},{66:[1,32],80:46},{21:[2,42],31:[2,42],52:[2,42],59:[2,42],62:[2,42],66:[2,42],69:[2,42],74:[2,42],75:[2,42],76:[2,42],77:[2,42],78:[2,42],79:[2,42],81:[2,42]},{50:47,52:[2,77],59:[2,77],66:[2,77],74:[2,77],75:[2,77],76:[2,77],77:[2,77],78:[2,77],79:[2,77]},{23:48,36:50,37:[1,52],41:51,42:[1,53],43:49,45:[2,49]},{26:54,41:55,42:[1,53],45:[2,51]},{16:[1,56]},{31:[2,81],55:57,59:[2,81],66:[2,81],74:[2,81],75:[2,81],76:[2,81],77:[2,81],78:[2,81],79:[2,81]},{31:[2,37],59:[2,37],66:[2,37],74:[2,37], | |
| 75:[2,37],76:[2,37],77:[2,37],78:[2,37],79:[2,37]},{31:[2,38],59:[2,38],66:[2,38],74:[2,38],75:[2,38],76:[2,38],77:[2,38],78:[2,38],79:[2,38]},{18:58,66:[1,32],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{28:59,31:[2,53],59:[2,53],66:[2,53],69:[2,53],74:[2,53],75:[2,53],76:[2,53],77:[2,53],78:[2,53],79:[2,53]},{31:[2,59],33:60,59:[2,59],66:[2,59],69:[2,59],74:[2,59],75:[2,59],76:[2,59],77:[2,59],78:[2,59],79:[2,59]},{19:61,21:[2,45],59:[2,45],66:[2,45],74:[2,45],75:[2,45],76:[2,45],77:[2,45],78:[2,45],79:[2,45]},{18:65,31:[2,75],48:62,57:63,58:66,59:[1,40],63:64,64:67,65:68,66:[1,69],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{66:[1,70]},{21:[2,39],31:[2,39],52:[2,39],59:[2,39],62:[2,39],66:[2,39],69:[2,39],74:[2,39],75:[2,39],76:[2,39],77:[2,39],78:[2,39],79:[2,39],81:[1,45]},{18:65,51:71,52:[2,79],57:72,58:66,59:[1,40],63:73,64:67,65:68,66:[1,69],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{24:74,45:[1,75]},{45:[2,50]},{4:76,6:3,13:[2,43],14:[2,43],17:[2,43],27:[2,43],32:[2,43],37:[2,43],42:[2,43],45:[2,43],46:[2,43],49:[2,43],53:[2,43]},{45:[2,19]},{18:77,66:[1,32],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{4:78,6:3,13:[2,43],14:[2,43],17:[2,43],27:[2,43],32:[2,43],45:[2,43],46:[2,43],49:[2,43],53:[2,43]},{24:79,45:[1,75]},{45:[2,52]},{5:[2,10],13:[2,10],14:[2,10],17:[2,10],27:[2,10],32:[2,10],37:[2,10],42:[2,10],45:[2,10],46:[2,10],49:[2,10],53:[2,10]},{18:65,31:[2,83],56:80,57:81,58:66,59:[1,40],63:82,64:67,65:68,66:[1,69],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{59:[2,85],60:83,62:[2,85],66:[2,85],74:[2,85],75:[2,85],76:[2,85],77:[2,85],78:[2,85],79:[2,85]},{18:65,29:84,31:[2,55],57:85,58:66,59:[1,40],63:86,64:67,65:68,66:[1,69],69:[2,55],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{18:65,31:[2,61],34:87,57:88,58:66,59:[1,40],63:89,64:67,65:68,66:[1,69],69:[2,61],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{18:65,20:90,21:[2,47],57:91,58:66,59:[1,40],63:92,64:67,65:68,66:[1,69],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{31:[1,93]},{31:[2,74],59:[2,74],66:[2,74],74:[2,74],75:[2,74],76:[2,74],77:[2,74],78:[2,74],79:[2,74]},{31:[2,76]},{21:[2,24],31:[2,24],52:[2,24],59:[2,24],62:[2,24],66:[2,24],69:[2,24],74:[2,24],75:[2,24],76:[2,24],77:[2,24],78:[2,24],79:[2,24]},{21:[2,25],31:[2,25],52:[2,25],59:[2,25],62:[2,25],66:[2,25],69:[2,25],74:[2,25],75:[2,25],76:[2,25],77:[2,25],78:[2,25],79:[2,25]},{21:[2,27],31:[2,27],52:[2,27],62:[2,27],65:94,66:[1,95],69:[2,27]},{21:[2,89],31:[2,89],52:[2,89],62:[2,89],66:[2,89],69:[2,89]},{21:[2,42],31:[2,42],52:[2,42],59:[2,42],62:[2,42],66:[2,42],67:[1,96],69:[2,42],74:[2,42],75:[2,42],76:[2,42],77:[2,42],78:[2,42],79:[2,42],81:[2,42]},{21:[2,41],31:[2,41],52:[2,41],59:[2,41],62:[2,41],66:[2,41],69:[2,41],74:[2,41],75:[2,41],76:[2,41],77:[2,41],78:[2,41],79:[2,41],81:[2,41]},{52:[1,97]},{52:[2,78],59:[2,78],66:[2,78],74:[2,78],75:[2,78],76:[2,78],77:[2,78],78:[2,78],79:[2,78]},{52:[2,80]},{5:[2,12],13:[2,12],14:[2,12],17:[2,12],27:[2,12],32:[2,12],37:[2,12],42:[2,12],45:[2,12],46:[2,12],49:[2,12],53:[2,12]},{18:98,66:[1,32],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{36:50,37:[1,52],41:51,42:[1,53],43:100,44:99,45:[2,71]},{31:[2,65],38:101,59:[2,65],66:[2,65],69:[2,65],74:[2,65],75:[2,65],76:[2,65],77:[2,65],78:[2,65],79:[2,65]},{45:[2,17]},{5:[2,13],13:[2,13],14:[2,13],17:[2,13],27:[2,13],32:[2,13],37:[2,13],42:[2,13],45:[2,13],46:[2,13],49:[2,13],53:[2,13]},{31:[1,102]},{31:[2,82],59:[2,82],66:[2,82],74:[2,82],75:[2,82],76:[2,82],77:[2,82],78:[2,82],79:[2,82]},{31:[2,84]},{18:65,57:104,58:66,59:[1,40],61:103,62:[2,87],63:105,64:67,65:68,66:[1,69],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{30:106,31:[2,57],68:107,69:[1,108]},{31:[2,54],59:[2,54],66:[2,54],69:[2,54],74:[2,54],75:[2,54],76:[2,54],77:[2,54],78:[2,54],79:[2,54]},{31:[2,56],69:[2,56]},{31:[2,63],35:109,68:110,69:[1,108]},{31:[2,60],59:[2,60],66:[2,60],69:[2,60],74:[2,60],75:[2,60],76:[2,60],77:[2,60],78:[2,60],79:[2,60]},{31:[2,62],69:[2,62]},{21:[1,111]},{21:[2,46],59:[2,46],66:[2,46],74:[2,46],75:[2,46],76:[2,46],77:[2,46],78:[2,46],79:[2,46]},{21:[2,48]},{5:[2,21],13:[2,21],14:[2,21],17:[2,21],27:[2,21],32:[2,21],37:[2,21],42:[2,21],45:[2,21],46:[2,21],49:[2,21],53:[2,21]},{21:[2,90],31:[2,90],52:[2,90],62:[2,90],66:[2,90],69:[2,90]},{67:[1,96]},{18:65,57:112,58:66,59:[1,40],66:[1,32],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{5:[2,22],13:[2,22],14:[2,22],17:[2,22],27:[2,22],32:[2,22],37:[2,22],42:[2,22],45:[2,22],46:[2,22],49:[2,22],53:[2,22]},{31:[1,113]},{45:[2,18]},{45:[2,72]},{18:65,31:[2,67],39:114,57:115,58:66,59:[1,40],63:116,64:67,65:68,66:[1,69],69:[2,67],72:23,73:24,74:[1,25],75:[1,26],76:[1,27],77:[1,28],78:[1,29],79:[1,31],80:30},{5:[2,23],13:[2,23],14:[2,23],17:[2,23],27:[2,23],32:[2,23],37:[2,23],42:[2,23],45:[2,23],46:[2,23],49:[2,23],53:[2,23]},{62:[1,117]},{59:[2,86],62:[2,86],66:[2,86],74:[2,86],75:[2,86],76:[2,86],77:[2,86],78:[2,86],79:[2,86]},{62:[2,88]},{31:[1,118]},{31:[2,58]},{66:[1,120],70:119},{31:[1,121]},{31:[2,64]},{14:[2,11]},{21:[2,28],31:[2,28],52:[2,28],62:[2,28],66:[2,28],69:[2,28]},{5:[2,20],13:[2,20],14:[2,20],17:[2,20],27:[2,20],32:[2,20],37:[2,20],42:[2,20],45:[2,20],46:[2,20],49:[2,20],53:[2,20]},{31:[2,69],40:122,68:123,69:[1,108]},{31:[2,66],59:[2,66],66:[2,66],69:[2,66],74:[2,66],75:[2,66],76:[2,66],77:[2,66],78:[2,66],79:[2,66]},{31:[2,68],69:[2,68]},{21:[2,26],31:[2,26],52:[2,26],59:[2,26],62:[2,26],66:[2,26],69:[2,26],74:[2,26],75:[2,26],76:[2,26],77:[2,26],78:[2,26],79:[2,26]},{13:[2,14],14:[2,14],17:[2,14],27:[2,14],32:[2,14],37:[2,14],42:[2,14],45:[2,14],46:[2,14],49:[2,14],53:[2,14]},{66:[1,125],71:[1,124]},{66:[2,91],71:[2,91]},{13:[2,15],14:[2,15],17:[2,15],27:[2,15],32:[2,15],42:[2,15],45:[2,15],46:[2,15],49:[2,15],53:[2,15]},{31:[1,126]},{31:[2,70]},{31:[2,29]},{66:[2,92],71:[2,92]},{13:[2,16],14:[2,16],17:[2,16],27:[2,16],32:[2,16],37:[2,16],42:[2,16],45:[2,16],46:[2,16],49:[2,16],53:[2,16]}],defaultActions:{4:[2,1],49:[2,50],51:[2,19],55:[2,52],64:[2,76],73:[2,80],78:[2,17],82:[2,84],92:[2,48],99:[2,18],100:[2,72],105:[2,88],107:[2,58],110:[2,64],111:[2,11],123:[2,70],124:[2,29]},parseError:function(a,b){throw new Error(a)},parse:function(a){function b(){var a;return a=c.lexer.lex()||1,"number"!=typeof a&&(a=c.symbols_[a]||a),a}var c=this,d=[0],e=[null],f=[],g=this.table,h="",i=0,j=0,k=0;this.lexer.setInput(a),this.lexer.yy=this.yy,this.yy.lexer=this.lexer,this.yy.parser=this,"undefined"==typeof this.lexer.yylloc&&(this.lexer.yylloc={});var l=this.lexer.yylloc;f.push(l);var m=this.lexer.options&&this.lexer.options.ranges;"function"==typeof this.yy.parseError&&(this.parseError=this.yy.parseError);for(var n,o,p,q,r,s,t,u,v,w={};;){if(p=d[d.length-1],this.defaultActions[p]?q=this.defaultActions[p]:((null===n||"undefined"==typeof n)&&(n=b()),q=g[p]&&g[p][n]),"undefined"==typeof q||!q.length||!q[0]){var x="";if(!k){v=[];for(s in g[p])this.terminals_[s]&&s>2&&v.push("'"+this.terminals_[s]+"'");x=this.lexer.showPosition?"Parse error on line "+(i+1)+":\n"+this.lexer.showPosition()+"\nExpecting "+v.join(", ")+", got '"+(this.terminals_[n]||n)+"'":"Parse error on line "+(i+1)+": Unexpected "+(1==n?"end of input":"'"+(this.terminals_[n]||n)+"'"),this.parseError(x,{text:this.lexer.match,token:this.terminals_[n]||n,line:this.lexer.yylineno,loc:l,expected:v})}}if(q[0]instanceof Array&&q.length>1)throw new Error("Parse Error: multiple actions possible at state: "+p+", token: "+n);switch(q[0]){case 1:d.push(n),e.push(this.lexer.yytext),f.push(this.lexer.yylloc),d.push(q[1]),n=null,o?(n=o,o=null):(j=this.lexer.yyleng,h=this.lexer.yytext,i=this.lexer.yylineno,l=this.lexer.yylloc,k>0&&k--);break;case 2:if(t=this.productions_[q[1]][1],w.$=e[e.length-t],w._$={first_line:f[f.length-(t||1)].first_line,last_line:f[f.length-1].last_line,first_column:f[f.length-(t||1)].first_column,last_column:f[f.length-1].last_column},m&&(w._$.range=[f[f.length-(t||1)].range[0],f[f.length-1].range[1]]),r=this.performAction.call(w,h,j,i,this.yy,q[1],e,f),"undefined"!=typeof r)return r;t&&(d=d.slice(0,-1*t*2),e=e.slice(0,-1*t),f=f.slice(0,-1*t)),d.push(this.productions_[q[1]][0]),e.push(w.$),f.push(w._$),u=g[d[d.length-2]][d[d.length-1]],d.push(u);break;case 3:return!0}}return!0}},c=function(){var a={EOF:1,parseError:function(a,b){if(!this.yy.parser)throw new Error(a);this.yy.parser.parseError(a,b)},setInput:function(a){return this._input=a,this._more=this._less=this.done=!1,this.yylineno=this.yyleng=0,this.yytext=this.matched=this.match="",this.conditionStack=["INITIAL"],this.yylloc={first_line:1,first_column:0,last_line:1,last_column:0},this.options.ranges&&(this.yylloc.range=[0,0]),this.offset=0,this},input:function(){var a=this._input[0];this.yytext+=a,this.yyleng++,this.offset++,this.match+=a,this.matched+=a;var b=a.match(/(?:\r\n?|\n).*/g);return b?(this.yylineno++,this.yylloc.last_line++):this.yylloc.last_column++,this.options.ranges&&this.yylloc.range[1]++,this._input=this._input.slice(1),a},unput:function(a){var b=a.length,c=a.split(/(?:\r\n?|\n)/g);this._input=a+this._input,this.yytext=this.yytext.substr(0,this.yytext.length-b-1),this.offset-=b;var d=this.match.split(/(?:\r\n?|\n)/g);this.match=this.match.substr(0,this.match.length-1),this.matched=this.matched.substr(0,this.matched.length-1),c.length-1&&(this.yylineno-=c.length-1);var e=this.yylloc.range;return this.yylloc={first_line:this.yylloc.first_line,last_line:this.yylineno+1,first_column:this.yylloc.first_column,last_column:c?(c.length===d.length?this.yylloc.first_column:0)+d[d.length-c.length].length-c[0].length:this.yylloc.first_column-b},this.options.ranges&&(this.yylloc.range=[e[0],e[0]+this.yyleng-b]),this},more:function(){return this._more=!0,this},less:function(a){this.unput(this.match.slice(a))},pastInput:function(){var a=this.matched.substr(0,this.matched.length-this.match.length);return(a.length>20?"...":"")+a.substr(-20).replace(/\n/g,"")},upcomingInput:function(){var a=this.match;return a.length<20&&(a+=this._input.substr(0,20-a.length)),(a.substr(0,20)+(a.length>20?"...":"")).replace(/\n/g,"")},showPosition:function(){var a=this.pastInput(),b=new Array(a.length+1).join("-");return a+this.upcomingInput()+"\n"+b+"^"},next:function(){if(this.done)return this.EOF;this._input||(this.done=!0);var a,b,c,d,e;this._more||(this.yytext="",this.match="");for(var f=this._currentRules(),g=0;g<f.length&&(c=this._input.match(this.rules[f[g]]),!c||b&&!(c[0].length>b[0].length)||(b=c,d=g,this.options.flex));g++);return b?(e=b[0].match(/(?:\r\n?|\n).*/g),e&&(this.yylineno+=e.length),this.yylloc={first_line:this.yylloc.last_line,last_line:this.yylineno+1,first_column:this.yylloc.last_column,last_column:e?e[e.length-1].length-e[e.length-1].match(/\r?\n?/)[0].length:this.yylloc.last_column+b[0].length},this.yytext+=b[0],this.match+=b[0],this.matches=b,this.yyleng=this.yytext.length,this.options.ranges&&(this.yylloc.range=[this.offset,this.offset+=this.yyleng]),this._more=!1,this._input=this._input.slice(b[0].length),this.matched+=b[0],a=this.performAction.call(this,this.yy,this,f[d],this.conditionStack[this.conditionStack.length-1]),this.done&&this._input&&(this.done=!1),a?a:void 0):""===this._input?this.EOF:this.parseError("Lexical error on line "+(this.yylineno+1)+". Unrecognized text.\n"+this.showPosition(),{text:"",token:null,line:this.yylineno})},lex:function(){var a=this.next();return"undefined"!=typeof a?a:this.lex()},begin:function(a){this.conditionStack.push(a)},popState:function(){return this.conditionStack.pop()},_currentRules:function(){return this.conditions[this.conditionStack[this.conditionStack.length-1]].rules},topState:function(){return this.conditionStack[this.conditionStack.length-2]},pushState:function(a){this.begin(a)}};return a.options={},a.performAction=function(a,b,c,d){function e(a,c){return b.yytext=b.yytext.substr(a,b.yyleng-c)}switch(c){case 0:if("\\\\"===b.yytext.slice(-2)?(e(0,1),this.begin("mu")):"\\"===b.yytext.slice(-1)?(e(0,1),this.begin("emu")):this.begin("mu"),b.yytext)return 14;break;case 1:return 14;case 2:return this.popState(),14;case 3:return b.yytext=b.yytext.substr(5,b.yyleng-9),this.popState(),16;case 4:return 14;case 5:return this.popState(),13;case 6:return 59;case 7:return 62;case 8:return 17;case 9:return this.popState(),this.begin("raw"),21;case 10:return 53;case 11:return 27;case 12:return 45;case 13:return this.popState(),42;case 14:return this.popState(),42;case 15:return 32;case 16:return 37;case 17:return 49;case 18:return 46;case 19:this.unput(b.yytext),this.popState(),this.begin("com");break;case 20:return this.popState(),13;case 21:return 46;case 22:return 67;case 23:return 66;case 24:return 66;case 25:return 81;case 26:break;case 27:return this.popState(),52;case 28:return this.popState(),31;case 29:return b.yytext=e(1,2).replace(/\\"/g,'"'),74;case 30:return b.yytext=e(1,2).replace(/\\'/g,"'"),74;case 31:return 79;case 32:return 76;case 33:return 76;case 34:return 77;case 35:return 78;case 36:return 75;case 37:return 69;case 38:return 71;case 39:return 66;case 40:return 66;case 41:return"INVALID";case 42:return 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| $(".entry-alert").delay(2e3).fadeOut("slow")})},function(a){$(function(){$("#inputOptionDiv").append('<div class="alert alert-danger entry-alert" role="alert">This accession is not available !</div>')}),console.error("Failed!",a)}))})}"pro"!==c.getEnvironment()&&$("body").append("<span style='position: absolute; top: 0; left: 0; border: 0; color: darkred; margin: 20px; font-weight: bold'>"+c.getEnvironment().toUpperCase()+" API</span>")}),this.HBtemplates=this.HBtemplates||{},this.HBtemplates["templates/overviewProtein.tmpl"]=Handlebars.template({1:function(a,b,c,d){var e,f,g,h=' <div id="cleavage-less" class="row">\n <div class="col-md-3 col-xs-3" style="color: grey;text-align:right">Cleaved into :</div>\n <div class="col-md-6 col-xs-6">';return f=null!=(f=b.cleavage||(null!=a?a.cleavage:a))?f:b.helperMissing,g={name:"cleavage",hash:{},fn:this.program(2,d,0),inverse:this.noop,data:d},e="function"==typeof f?f.call(a,g):f,b.cleavage||(e=b.blockHelperMissing.call(a,e,g)),null!=e&&(h+=e),h+"</div>\n </div>\n"},2:function(a,b,c,d){var e;return"<span>"+this.escapeExpression((e=null!=(e=b.synonymName||(null!=a?a.synonymName:a))?e:b.helperMissing,"function"==typeof e?e.call(a,{name:"synonymName",hash:{},data:d}):e))+", </span>"},4:function(a,b,c,d){var e;return' <div id="synonym-less" class="row">\n <div class="col-md-3 col-xs-3" style="color: grey;text-align:right">Protein also known as :</div>\n <div class="col-md-6 col-xs-6">'+this.escapeExpression(this.lambda(null!=(e=null!=a?a.recommendedProteinName:a)?e.synonymName:e,a))+"</div>\n </div>\n"},6:function(a,b,c,d){var e,f,g,h=' <div id="family-less" class="row">\n <div class="col-md-3 col-xs-3" style="color: grey;text-align:right">Family Name :</div>\n <div class="col-md-6 col-xs-6">';return f=null!=(f=b.family||(null!=a?a.family:a))?f:b.helperMissing,g={name:"family",hash:{},fn:this.program(7,d,0),inverse:this.noop,data:d},e="function"==typeof f?f.call(a,g):f,b.family||(e=b.blockHelperMissing.call(a,e,g)),null!=e&&(h+=e),h+"</div>\n </div>\n"},7:function(a,b,c,d){var e;return"<span>"+(null!=(e=(b.link_to||a&&a.link_to||b.helperMissing).call(a,"term",{name:"link_to",hash:{},data:d}))?e:"")+"</span>"},9:function(a,b,c,d){var e,f,g,h=b.helperMissing,i="function",j=" <dd>"+this.escapeExpression((f=null!=(f=b.name||(null!=a?a.name:a))?f:h,typeof f===i?f.call(a,{name:"name",hash:{},data:d}):f))+" "+(null!=(e=b["if"].call(a,null!=a?a.EC:a,{name:"if",hash:{},fn:this.program(10,d,0),inverse:this.noop,data:d}))?e:"")+" ";return f=null!=(f=b["short"]||(null!=a?a["short"]:a))?f:h,g={name:"short",hash:{},fn:this.program(14,d,0),inverse:this.noop,data:d},e=typeof f===i?f.call(a,g):f,b["short"]||(e=b.blockHelperMissing.call(a,e,g)),null!=e&&(j+=e),j+"</dd>\n"},10:function(a,b,c,d){var e,f,g,h="[";return f=null!=(f=b.EC||(null!=a?a.EC:a))?f:b.helperMissing,g={name:"EC",hash:{},fn:this.program(11,d,0),inverse:this.noop,data:d},e="function"==typeof f?f.call(a,g):f,b.EC||(e=b.blockHelperMissing.call(a,e,g)),null!=e&&(h+=e),h+" ] "},11:function(a,b,c,d){var e;return" "+(null!=(e=(b.link_to||a&&a.link_to||b.helperMissing).call(a,"EC",{name:"link_to",hash:{},data:d}))?e:"")+" "+(null!=(e=b.unless.call(a,d&&d.last,{name:"unless",hash:{},fn:this.program(12,d,0),inverse:this.noop,data:d}))?e:"")+" "},12:function(a,b,c,d){return","},14:function(a,b,c,d){return'<em style="font-size:12px;">(short : '+this.escapeExpression(this.lambda(a,a))+") </em>"},16:function(a,b,c,d){var e,f,g,h=" <dt>Cleaved into the following "+this.escapeExpression(this.lambda(null!=(e=null!=a?a.cleavage:a)?e.length:e,a))+" chains</dt>\n";return f=null!=(f=b.cleavage||(null!=a?a.cleavage:a))?f:b.helperMissing,g={name:"cleavage",hash:{},fn:this.program(17,d,0),inverse:this.noop,data:d},e="function"==typeof f?f.call(a,g):f,b.cleavage||(e=b.blockHelperMissing.call(a,e,g)),null!=e&&(h+=e),h},17:function(a,b,c,d){var e;return" <dd>"+this.escapeExpression((e=null!=(e=b.synonymName||(null!=a?a.synonymName:a))?e:b.helperMissing,"function"==typeof e?e.call(a,{name:"synonymName",hash:{},data:d}):e))+"</dd>\n "},19:function(a,b,c,d){var e,f,g,h=" <dt>Alternative Name</dt>\n";return f=null!=(f=b.alternativeProteinNames||(null!=a?a.alternativeProteinNames:a))?f:b.helperMissing,g={name:"alternativeProteinNames",hash:{},fn:this.program(20,d,0),inverse:this.noop,data:d},e="function"==typeof f?f.call(a,g):f,b.alternativeProteinNames||(e=b.blockHelperMissing.call(a,e,g)),null!=e&&(h+=e),h},20:function(a,b,c,d){var e,f;return" <dd> "+this.escapeExpression((f=null!=(f=b.name||(null!=a?a.name:a))?f:b.helperMissing,"function"==typeof f?f.call(a,{name:"name",hash:{},data:d}):f))+"\n "+(null!=(e=b["if"].call(a,null!=a?a["short"]:a,{name:"if",hash:{},fn:this.program(21,d,0),inverse:this.noop,data:d}))?e:"")+"\n </dd>\n "},21:function(a,b,c,d){var e;return'<em style="font-size:12px;">(short : '+this.escapeExpression(this.lambda(null!=(e=null!=(e=null!=a?a["short"]:a)?e[0]:e)?e.synonymName:e,a))+") </em>"},23:function(a,b,c,d){var e,f;return" <dd>"+this.escapeExpression((f=null!=(f=b.name||(null!=a?a.name:a))?f:b.helperMissing,"function"==typeof f?f.call(a,{name:"name",hash:{},data:d}):f))+"</dd>\n"+(null!=(e=b["if"].call(a,null!=a?a.synonyms:a,{name:"if",hash:{},fn:this.program(24,d,0),inverse:this.noop,data:d}))?e:"")+(null!=(e=b["if"].call(a,null!=a?a.orf:a,{name:"if",hash:{},fn:this.program(27,d,0),inverse:this.noop,data:d}))?e:"")},24:function(a,b,c,d){var e,f,g,h=" <dt>Alternative Names</dt>\n";return f=null!=(f=b.synonyms||(null!=a?a.synonyms:a))?f:b.helperMissing,g={name:"synonyms",hash:{},fn:this.program(25,d,0),inverse:this.noop,data:d},e="function"==typeof f?f.call(a,g):f,b.synonyms||(e=b.blockHelperMissing.call(a,e,g)),null!=e&&(h+=e),h},25:function(a,b,c,d){var e;return" <dd> "+this.escapeExpression((e=null!=(e=b.name||(null!=a?a.name:a))?e:b.helperMissing,"function"==typeof e?e.call(a,{name:"name",hash:{},data:d}):e))+"</dd>\n"},27:function(a,b,c,d){var e,f,g,h=" <dt>ORF names</dt>\n";return f=null!=(f=b.orf||(null!=a?a.orf:a))?f:b.helperMissing,g={name:"orf",hash:{},fn:this.program(25,d,0),inverse:this.noop,data:d},e="function"==typeof f?f.call(a,g):f,b.orf||(e=b.blockHelperMissing.call(a,e,g)),null!=e&&(h+=e),h},29:function(a,b,c,d){var e,f,g,h=' <div id="family-full" class="row">\n <div class="col-md-2 col-xs-3 text-uppercase" style="color: grey;">Family</div>\n <div class="col-md-7 col-xs-6">\n <dl>\n <dt>Family</dt>\n';return f=null!=(f=b.family||(null!=a?a.family:a))?f:b.helperMissing,g={name:"family",hash:{},fn:this.program(30,d,0),inverse:this.noop,data:d},e="function"==typeof f?f.call(a,g):f,b.family||(e=b.blockHelperMissing.call(a,e,g)),null!=e&&(h+=e),h+" </dl>\n </div>\n </div>\n"},30:function(a,b,c,d){var e;return" <dd>"+(null!=(e=(b.link_to||a&&a.link_to||b.helperMissing).call(a,"term",{name:"link_to",hash:{},data:d}))?e:"")+"</dd>\n"},32:function(a,b,c,d){var e;return null!=(e=(b.link_to||a&&a.link_to||b.helperMissing).call(a,"history",{name:"link_to",hash:{},data:d}))?e:""},compiler:[6,">= 2.0.0-beta.1"],main:function(a,b,c,d){var e,f,g,h=b.helperMissing,i="function",j=this.escapeExpression,k=b.blockHelperMissing,l='<div id="proteinTitle">\n <button id="extender" class="btn btn-default" style="float:right">Extend overview</button>\n <h2>'+j((f=null!=(f=b.entryName||(null!=a?a.entryName:a))?f:h,typeof f===i?f.call(a,{name:"entryName",hash:{},data:d}):f))+'</h2>\n</div>\n<div id="INFOS-LESS" style="display:block">\n'+(null!=(e=b["if"].call(a,null!=a?a.cleavage:a,{name:"if",hash:{},fn:this.program(1,d,0),inverse:this.noop,data:d}))?e:"")+(null!=(e=b["if"].call(a,null!=(e=null!=a?a.recommendedProteinName:a)?e.synonymName:e,{name:"if",hash:{},fn:this.program(4,d,0),inverse:this.noop,data:d}))?e:"")+' <div id="gene-less" class="row">\n <div class="col-md-3 col-xs-3" style="color: grey;text-align:right">Gene Name :</div>\n <div class="col-md-6 col-xs-6">'+j(this.lambda(null!=(e=null!=(e=null!=a?a.geneName:a)?e[0]:e)?e.name:e,a))+"</div>\n </div>\n"+(null!=(e=b["if"].call(a,null!=a?a.family:a,{name:"if",hash:{},fn:this.program(6,d,0),inverse:this.noop,data:d}))?e:"")+'</div>\n<div id="INFOS-FULL" style="display:none">\n <div id="protein-full" class="row">\n <div class="col-md-2 col-xs-3 text-uppercase" style="color: grey;">Protein</div>\n <div class="col-md-7 col-xs-6">\n <dl>\n <dt>Recommended Name</dt>\n';return f=null!=(f=b.recommendedProteinName||(null!=a?a.recommendedProteinName:a))?f:h,g={name:"recommendedProteinName",hash:{},fn:this.program(9,d,0),inverse:this.noop,data:d},e=typeof f===i?f.call(a,g):f,b.recommendedProteinName||(e=k.call(a,e,g)),null!=e&&(l+=e),l+=(null!=(e=b["if"].call(a,null!=a?a.cleavage:a,{name:"if",hash:{},fn:this.program(16,d,0),inverse:this.noop,data:d}))?e:"")+"\n"+(null!=(e=b["if"].call(a,null!=a?a.alternativeProteinNames:a,{name:"if",hash:{},fn:this.program(19,d,0),inverse:this.noop,data:d}))?e:"")+'\n </dl>\n </div>\n </div>\n <div id="gene-full" class="row">\n <div class="col-md-2 col-xs-3 text-uppercase" style="color: grey;">Gene</div>\n <div class="col-md-7 col-xs-6">\n <dl>\n <dt>Recommended Name</dt>\n',f=null!=(f=b.geneName||(null!=a?a.geneName:a))?f:h,g={name:"geneName",hash:{},fn:this.program(23,d,0),inverse:this.noop,data:d},e=typeof f===i?f.call(a,g):f,b.geneName||(e=k.call(a,e,g)),null!=e&&(l+=e),l+=" </dl>\n </div>\n </div>\n"+(null!=(e=b["if"].call(a,null!=a?a.family:a,{name:"if",hash:{},fn:this.program(29,d,0),inverse:this.noop,data:d}))?e:"")+' <div id="History-full" class="row">\n <div class="col-md-2 col-xs-3 text-uppercase" style="color: grey;">History</div>\n <div class="col-md-7 col-xs-6">\n <dl>\n <dt>neXtProt</dt>\n <dd>Integrated '+j((f=null!=(f=b.integDate||(null!=a?a.integDate:a))?f:h,typeof f===i?f.call(a,{name:"integDate",hash:{},data:d}):f))+"</dd>\n <dd>Last Updated "+j((f=null!=(f=b.lastUpdate||(null!=a?a.lastUpdate:a))?f:h,typeof f===i?f.call(a,{name:"lastUpdate",hash:{},data:d}):f))+"</dd>\n <dt>UniProtKB</dt>\n <dd>Entry version "+j((f=null!=(f=b.version||(null!=a?a.version:a))?f:h,typeof f===i?f.call(a,{name:"version",hash:{},data:d}):f))+"</dd>\n <dd>Integration Date "+j((f=null!=(f=b.UniprotIntegDate||(null!=a?a.UniprotIntegDate:a))?f:h,typeof f===i?f.call(a,{name:"UniprotIntegDate",hash:{},data:d}):f))+"</dd>\n <dd>Last Update "+j((f=null!=(f=b.UniProtLastUpdate||(null!=a?a.UniProtLastUpdate:a))?f:h,typeof f===i?f.call(a,{name:"UniProtLastUpdate",hash:{},data:d}):f))+"</dd>\n <dd>Sequence version "+j((f=null!=(f=b.seqVersion||(null!=a?a.seqVersion:a))?f:h,typeof f===i?f.call(a,{name:"seqVersion",hash:{},data:d}):f))+"</dd>\n <dd>",f=null!=(f=b.accessionNumber||(null!=a?a.accessionNumber:a))?f:h,g={name:"accessionNumber",hash:{},fn:this.program(32,d,0),inverse:this.noop,data:d},e=typeof f===i?f.call(a,g):f,b.accessionNumber||(e=k.call(a,e,g)),null!=e&&(l+=e),l+'</dd>\n </dl>\n </div>\n </div>\n</div>\n<p style="margin:10px 10px;">Entry whose protein(s) existence is based on '+j((f=null!=(f=b.proteineEvidence||(null!=a?a.proteineEvidence:a))?f:h,typeof f===i?f.call(a,{name:"proteineEvidence",hash:{},data:d}):f))+"</p>"},useData:!0}); | |
| //# sourceMappingURL=nextprot.bundle.js.map |
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